Top 10 Innovations 2015

1. GemCode Platform | 10X Genomics

These days it seems like more labs than not are equipped to do their own DNA sequencing, most commonly using an Illumina desktop system. While these sequencers are user-friendly and quick to produce data, they generate reads of only a few hundred base pairs, meaning much long-range genomic information—such as structural variants, polymorphisms, and haplotypes—is lost.

10X Genomics aims to solve that problem with its GemCode Platform, released this summer. An all-in-one molecular barcoding and analysis tool, GemCode partitions very large DNA molecules—100 kilobases, on average—into gel beads, and then tags these fragments with a specific oligo that will be sequenced along with the DNA after it’s broken down to be compatible with Illumina sequencers. The oligo tags then allow the analysis software to reconstruct accurate, long-range genomic information.

“There’s been this growing realization in the community and market that huge amounts of information are missing from our genome sequencing,” says 10X Genomics CEO and founder Serge Saxonov. “We solve that . . . by barcoding.”
The system costs $75,000 and is compatible with Illumina sequencers……..More

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